Arguments have raged over the differences between hospitalised and non hosp LC.
This paper has just found non-hosp has more thrombotic events and more fatigue. Defo think there’s a different disease ‘engine’ driving ‘mild’ acute cases that develop LC.
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My overly-simplistic take on this is that the difference between hospitalised / non-hospitalised and post covid symptoms are whether the acute infection goes hardcore in your respiratory system or your gut.
Got a bit of data to back this up from my early studies.
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@gezmedinger
Or it means that mild was actually not mild, and these patients should have been treated
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@KnoopsRob
Treated, for sure! But not necessarily so ill that they couldn’t recover from the acute phase without needing hospitalisation.
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@gezmedinger
In Uganda most the "older" adults amongst my family and friends were hospitalised with covid as precaution. Most had diabetes, heart issues etc and all given ivm, dexamethasone, anticoagulants etc. None went on to develop long covid.
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@Nishi_Damani
Very interesting! Does seem like there’s something about letting the virus rampage unchecked that means it gets into the wrong nooks and crannies and doesn’t come out again… (maybe)
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@gezmedinger
You've probably covered this Gez
If you have, please link
But the gut really irritates me
Literally & notionally
I know it's involved
My GI symptoms are improved lately
I'd like to do more
I don't seem to have reflux
Just bloating & painful burping
Goes with the hard swallow
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@gezmedinger
I explain this... So covid hijacks cells in a chain... it has access to ACE2 first normally but Omi uses Endolysosomes.
This means that it has less access to cytokine-creating cells at the start but the viral syncytia is the same as far as clotting.
Also, syncytia bursts more
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@gezmedinger
Another possibility is that hospital treatments such as oxygen, steroids, and blood thinners are reducing long term effects.
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@gezmedinger
I'd really like to see a wider use of antivirals in the UK
People are struggling at home to shift the virus, often testing positive for days
A GP told me he tested positive for ten days
that is never a good scenario
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@gezmedinger
This seems to be consistent with APS patients currently on treatment for clotting seem to be doing ok with COVID. Sharing in case it helps.
@Emiel_1985
Fortunately, we haven't seen that. Most people with APS are already on all the right treatments. As such, one could theorize that they are in better shape than the general population.
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@gezmedinger
I think that it is because they got blood thinners, oxygen, nitric oxide, steroids, etc. I got a phone call 2 weeks later. And, they were "forced" to rest. I continued working (teaching online) even when it was hard to stand up. Women=moms=no rest=long covid?
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@gezmedinger
Mild = weak immune response = virus persistent, sever = strong immune response, no virus but damage to the body from the immune response itself
Been saying this for 1.5 years
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@Daltmann10
It’s because non-hosp patients did not receive any treatment, whereas hospitalised patients received suppl oxygen+antiviral+immunosuppressive therapy. This also clearly affects the long term outcomes of the illness.
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@gezmedinger
This small study show viral persistence in the group who did not get treatment.
This is only looking at one side. Inflammation is key in my case.
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@gezmedinger
Another contributor could be that many (not all) hospitalised patients get anticoagulation now. Not a single acute patient treated by Jaco Laubscher went on to develop
#LongCovid
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@gezmedinger
Along with these very sensible theories, maybe people with mild infections also don’t rest enough during/following the acute phase. Hospitalization strongly signals „this is serious, take rest to recover“. And we all know now prolonged rest is so important against
#LongCovid
.
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